Glaze (r) Tablets Gliclazide
Oral Hypoglycemic Agent
   
COMPOSITION Each tablet contains 80mg gliclazide.
   
INDICATIONS Glaze is indicated to control hyperglycemia in non acidotic, non ketotic type 2 diabetics who can not achieve adequate glycemic control by diet and exercise alone.
   
DOSAGE AND ADMINISTRATION

The usual initial dose in non-insulin dependent diabetics is 40 - 80 mg daily by oral route, to be gradually increased, if necessary, up to 320 mg daily.
Doses of more than 160 mg daily should be divided into 2 according to the main meals of the day.
   
CONTRAINDICATIONS * Type 1 diabetes mellitus
* Severe ketosis, acidosis
* Diabetic coma and initial stage of diabetic coma
* Pregnancy, lactation
* Known hypersensitivity to sulfonamides
* Combination with miconazole tablets.
   
PRECAUTIONS
Physician's dietary recommendations should be followed while using gliclazide. They will enhance gliclazide's efficacy.
There are certain drugs, which may increase or decrease gliclazide hypoglycemic effect. The physician must be informed about the drugs the patient are taking so that he can adjust the dosage, if necessary.
Certain drugs have the potential to increase gliclazide's hypoglycemic effect, e.g.
- Non-steroidal anti-inflammatory drugs (in particular, aspirin)
- Antibacterial sulfonamides, coumarin anti- coagulants, MAOIs, beta-blockers, perhexiline maleate, chloramphenicol, clofibrate, and miconazole tablets.
- Administration of alcohol may also increase the hypoglycemic effect of gliclazide.
Some drugs, on the contrary may, reduce gliclazide's effectiveness, e.g.
- Barbiturates, corticosteroids, thiazide diuretics and oral contraceptives.
High doses or a low-carbohydrate or unbalanced carbohydrate diet may lead to an excessive decrease in blood sugar (hypoglycemia). Hypoglycemia is manifested by a feeling of malaise, sweating, pallor, hunger pangs, increased heart rate.
In this case:
* Some sugar should be taken and physician should be informed.
* Caution is needed in the elderly or those with hepatic and renal insufficiency because of the hazard of hypoglycemia.
   
SIDE EFFECTS The side effects are very rare with Glaze but like other oral hypoglycemics the following may occur :
mucocutaneous reactions, blood disorders, minor gastrointestinal disorders, hepatic disorders; in this case physician should be consulted.
   
OVERDOSAGE

Overdosage leads essentially to hypoglycemia. In severe cases, if there is clouding of consciousness, 10% or 30% hypertonic glucose must be administered intravenously without delay and the patient transferred to a hospital urgently.
   
PRESENTATIONS Glaze is available in 80 mg tablets formulation.