CLOVIRŪ
Cream Antiviral

Composition | Properties | Indications | Dosage & Administration | Contraindications | Precautions | Mutagenicity | Carcinogenicity | Effects On Fertility | Side Effects | Over Dosage | Presentations

COMPOSITION
Each gram contains 50 mg Acyclovir in a water-miscible base.

PROPERTIES
Acyclovir is an anti-viral agent, which is highly active in vitro against herpes simplex virus, Types I & II and varicella Zoster virus. Acyclovir is phosphorylated after entry into herpes-infected cells to the active compound acyclovir triphosphate; this is dependent on the presence of viral coded thymidine kinase. Acyclovir triphosphate acts as an inhibitor of, and substrate for, the herpes-specified DNA polymerase preventing further viral DNA synthesis without affecting normal cellular processes.

INDICATIONS
CLOVIR cream is indicated for the treatment of herpes simplex virus infection of the skin including initial and recurrent genital herpes and herpes labialis.

DOSAGE AND ADMINISTRATION
For adults and children, CLOVIR cream should be applied five times daily. CLOVIR cream should be applied as early as possible after the start of an infection. Treatment should be continued for five days and can be extended up to 10 days if healing has not occurred.

CONTRAINDICATIONS
Hypersensitivity to Acyclovir. In pregnancy and lactation, experience in humans is limited, so the use of CLOVIR cream should be considered only when the potential benefits outweigh the possibility of unknown risks.

PRECAUTIONS
CLOVIR cream is not recommended to be applied to the eye or to mucous membrane, e.g. mouth or vagina.

MUTAGENICITY
In vitro and in vivo studies indicate that acyclovir does not pose a genetic risk to man.

CARCINOGENICITY
In long term studies acyclovir was not found to be carcinogenic in the rat and in the mouse.

EFFECTS ON FERTILITY
There is no experience on the effect of CLOVIR cream on human female fertility.

SIDE EFFECTS
Transient burning or stringing may occur in some patients following the application of CLOVIR cream, mild drying and flaking of the skin has occurred. Erythema and itching have been reported in a small number of patients.

OVER DOSAGE
No untoward effects would be expected if the entire contents of a 10g tube of CLOVIR cream containing 500 mg of acyclovir were ingested orally.

PRESENTATIONS
Tube of 10 grams: box of 100 tubes.