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DIATAB®
Oral
Hypoglycemic
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COMPOSITION
Each
tablet contains 5 mg Glibenclamide B.P.
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PROPERTIES
DIATAB
is a sulphonylurea possessing a hypoglycemic action by oral route.
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INDICATIONS
Certain
forms of diabetes (type II, maturity-onset diabetes) which are not
adequately controlled by dietary measures alone
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DOSAGE
AND ADMINISTRATION
Initial
stabilization on DIATAB must be undertaken by a physician's consultation
only. The treatment is started with half a tablet of DIATAB (2.5mg)
immediately before breakfast. If necessary, raise the dose by 2.5
mg at intervals of one week until the blood sugar is controlled.
As a rule, the maximum effect is attained with 3 tablets of DIATAB
per day, in exceptional cases 4 tablets of DIATAB
per day .The maximum single dose is 2 tablets of DIATAB to
be taken before breakfast. If the daily dose exceeds 2 tablets the
remaining portion is taken immediately before the evening meal.
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CONTRAINDICATIONS
Insulin-dependent
(type 1) diabetes, diabetic coma, breakdown of control of diabetes
e.g kotacidosis, precoma, severe renal or hepatic impairment, hypersensitivity
to Glibenclamide, pregnancy and lactation (consult a physician for
advice).
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PRECAUTIONS
Change over from another antidiabetic agent,
especially insulin to DIATAB, or to be combined, therapy should
be carried out under medical supervision.
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SIDE
EFFECTS
Exceptional
cases of gastric intolerance and allergic skin reactions. Rare and
reversible hemopoietic system changes.
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INTERACTIONS
Some
drugs may potentiate the hypoglycemic action of DIATAB ( e.g. betablockers,
bezafibrate, clofibrate, coumarin derivative, chloramphenicol, biguanides,
fenfluramin, pentoxifylline, monoamine oxidase inhibitors, phenylbutazone,
salicylates, phosphamides, phenyramidol, sulphonamides, sulphinpyrazone
& tetracycline compounds). Some other drugs may decrease the hypoglycemic
action of DIATAB (e.g. abuse of laxatives & high dosage of nicotinic
acid) estrogen, gestagens, corticosteroids, phenothiazine derivatives,
saluretics, sympathomimetic agents & thyroid hormones.
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SPECIAL
NOTES
Compliance to diet and regular DIATAB intake
are of utmost importance. Overdosage, interaction, or dietary errors
may lead to hypoglycemic episodes (headache, irritability, restlessness,
profuse sweating, insomnia, tremor, impairment of performance and
alertness) which must be immediately reported to the physician.
In this case the patient may not be fit to drive, to cross the road
or to operate machinery. Sign of hypoglycemia can be corrected by
administering carbohydrates (sugar in various forms). When situation
of unusual stress arises ( e.g. emergency surgery & febrile infections)
a temporary change to insulin may become necessary.
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PRESENTATIONS
5 mg tablet in
packs of 30 tablets & hospital packs of 1000 tablets.
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